Neural mechanisms mediating appetitive regulation and smoking in nicotine addiction
|
University of Utah Principal Investigator (PI) / Project Lead: |
GARLAND, ERIC |
|
Prime/Overall Principal Investigator (PI) / Project Lead: |
Froeliger, Brett, PhD, at University of Missouri-Columbia |
|
Funding Organization: |
National Institutes of Health, National Institute on Drug Abuse |
|
RFP / FOA Number: |
PA-18-055 |
|
Award Number: |
R01DA048094 |
|
Funding Period: |
6/1/2019 – 3/31/2024 |
|
Total Funding: |
$2,218,299 |
|
Project Status: |
Ended |
Project Description:
Nicotine addiction is a chronic, relapsing brain disorder and although it is the leading cause of preventable premature death in the US, ~20% of adults smoke and among those that try to quit, the majority relapse. Preclinical and Human models suggest that nicotine addiction disrupts neural function in a corticostriatal network involved in motivation and reward. The overarching goal of this proposal is to utilize clinical neuroscience to investigate the effects of Mindfulness Oriented Recovery Enhancement (MORE) on corticostriatal circuitry function, regulation of appetitive processes and determine the value of this cognitive training for treating nicotine addiction.