Neuroimaging response inhibition and salience attribution changes during mindfulness-based treatment of human heroin addiction
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University of Utah Investigator / Project Lead: |
GARLAND, ERIC |
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Prime/Overall Principal Investigator (PI) / Project Lead: |
Goldstein, Rita Z., PhD, at Icahn School of Medicine at Mount Sinai |
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Funding Organization: |
National Institutes of Health, National Center for Complementary & Integrative Health |
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RFP / FOA Number: |
PA-18-345 |
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Award Numbers: |
R01AT010627 |
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Funding Period: |
8/15/2019 – 6/30/2024 |
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Total Funding: |
$3,775,359 |
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Project Status: |
Ended |
Project Description:
Drug overdose deaths in the US involving heroin nearly tripled during 2010–2015. Research into the enhancement of treatment options for individuals with opiate use disorder is therefore an imperative. Here we will use neuroimaging of reward processing, drug cue reactivity and inhibitory control before and immediately after 8-weeks of Mindfulness-Oriented Recovery Enhancement as compared to standard of care in opioid addiction; clinical outcomes will be assessed immediately and three months after treatment. Results could point to factors that track and predict recovery with treatment, offering clinicians markers that can be used for enhancing precision medicine with the goal of reducing morbidity and mortality associated with opiate addiction.